System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics

  title={System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics},
  author={Nikolaj Zuleger and David A. Kelly and A. Christine Richardson and Alastair R W Kerr and Martin W. Goldberg and Andrew B. Goryachev and Eric C Schirmer},
  booktitle={The Journal of cell biology},
The nuclear envelope contains >100 transmembrane proteins that continuously exchange with the endoplasmic reticulum and move within the nuclear membranes. To better understand the organization and dynamics of this system, we compared the trafficking of 15 integral nuclear envelope proteins using FRAP. A surprising 30-fold range of mobilities was observed. The dynamic behavior of several of these proteins was also analyzed after depletion of ATP and/or Ran, two functions implicated in… CONTINUE READING


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