System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate.

@article{Jenstad2009SystemAT,
  title={System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate.},
  author={Monica Jenstad and Abrar Z Quazi and Misha Zilberter and Camilla Hagler\od and Paul Berghuis and Navida Saddique and Michel Goiny and Doungjai Buntup and Svend Davanger and Finn-Mogens S Haug and Carol A. Barnes and Bruce L. McNaughton and Ole Petter Ottersen and Jon Storm-Mathisen and Tibor Harkany and Farrukh Abbas Chaudhry},
  journal={Cerebral cortex},
  year={2009},
  volume={19 5},
  pages={1092-106}
}
Glutamate mediates several modes of neurotransmission in the central nervous system including recently discovered retrograde signaling from neuronal dendrites. We have previously identified the system N transporter SN1 as being responsible for glutamine efflux from astroglia and proposed a system A transporter (SAT) in subsequent transport of glutamine into neurons for neurotransmitter regeneration. Here, we demonstrate that SAT2 expression is primarily confined to glutamatergic neurons in many… CONTINUE READING