Syringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma

@article{OpokuAnsah2012SyringolinBP,
  title={Syringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma},
  author={John Opoku-Ansah and Tannya R. Ibarra-Rivera and Michael C. Pirrung and Andr{\'e} S. Bachmann},
  journal={Pharmaceutical Biology},
  year={2012},
  volume={50},
  pages={25 - 29}
}
Context: The bacterium Pseudomonas syringae pv. syringae (Pss) is a pathogen of many plant species and causes, for example, brown spot disease in bean plants (Phaseolus vulgaris). Pss excretes the syringolins, natural product molecules that act as a virulence factors and inhibit the proteasome of the host plants. Objective: Proteasome inhibitors belong to an important class of anticancer agents and bortezomib (Velcade®) has been Food and Drug Administration-approved for the treatment of… 
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In this review, genes and protein products that are beneficial as drug targets in the treatment of neuroblastoma have been discussed and novel drug delivery systems with a focus on liposomes as carriers are discussed.
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