Syphilis treatment: old and new

@article{Dayan2005SyphilisTO,
  title={Syphilis treatment: old and new},
  author={Linda S Dayan and Catriona Ooi},
  journal={Expert Opinion on Pharmacotherapy},
  year={2005},
  volume={6},
  pages={2271 - 2280}
}
  • L. Dayan, C. Ooi
  • Published 1 October 2005
  • Medicine
  • Expert Opinion on Pharmacotherapy
Syphilis has challenged scientists and clinicians since its first appearance in the late 1400s and debate continues to surround the best practice in management. Difficulties in defining the goals of successful treatment have contributed to problems in determining recommendations for the ideal management. Treatment regimens currently in use were developed before randomised controlled trials became standard. This, combined with national differences in disease definition, staging and varying… 
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Clinical management of early syphilis
TLDR
Concerns about the potential for increased risk for treatment failure, patients with HIV and pregnant women are of particular concern, as doxycycline currently recommended as the main alternative to penicillin.
Clinical management of early
TLDR
Concerns about the potential for increased risk for treatment failure, patients with HIV and pregnant women are of particular concern, as doxycycline currently recommended as the main alternative to penicillin.
A Multicenter Study Evaluating Ceftriaxone and Benzathine Penicillin G as Treatment Agents for Early Syphilis in Jiangsu, China
  • Yuping Cao, X. Su, +13 authors Weida Liu
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    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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TLDR
Ceftriaxone regimen was noninferior to the BPG regimen in nonpregnant, immunocompetent patients with early syphilis.
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TLDR
All patients with ocular syphilis exhibited functional improvement and resolution of ocular inflammation after a specific antibiotic treatment, and syphilis should be considered in all patients with uveitis, scleritis, episcleritis or optic neuritis, especially in men with high-risk sexual behavior.
Syphilis, psychiatry and offending behaviour: clinical cases from nineteenth-century Ireland
  • B. Kelly
  • Medicine
    Irish journal of medical science
  • 2009
TLDR
The clinical and diagnostic challenges presented by syphilis have changed over the past century, but these cases, combined with recent evidence of syphilis outbreaks, highlight ongoing needs for clinical and epidemiological vigilance.
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The aetiology of microbial keratitis has changed greatly over the past century due to the discovery of antibiotics, improvement in sanitation and education, the rising trend of contact lens wear and increased air travel.
한국의 매독 포도막염의 임상양상
TLDR
A recent clinical manifestation of syphilitic uveitis in a Korean population is reported, indicating an increase of syphilis infections has become an issue in Korea as well as globally.
Availability of benzathine penicillin G for syphilis treatment in Shandong Province, Eastern China
TLDR
BPG availability for syphilis treatment in Shandong Province remains low and presents disparities among different levels and types of hospitals, although it has been improved in recent years.
[Osteoarticular manifestations of late congenital syphilis].
TLDR
The objective of this study was to establish whether the presence of a double stomach in an adult and a single stomach in a child under the age of 18 months indicates the need for further investigation into the causes of double stomachs in adults.
Neurology and Don Quixote
TLDR
This study aimed to read Don Quixote from a neurologist’s point of view, describing the neurological phenomena scattered throughout the novel, including tremors, sleep disturbances, neuropsychiatric symptoms, dementia, epilepsy, paralysis, stroke, syncope, traumatic head injury, and headache.
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