Syphilis

@article{Hook2017Syphilis,
  title={Syphilis},
  author={Edward W. Iii Hook},
  journal={The Indian Medical Gazette},
  year={2017},
  volume={55},
  pages={315 - 316}
}
  • E. Hook
  • Published 1 August 1920
  • Medicine
  • The Indian Medical Gazette
Syphilis is a chronic bacterial infection caused by Treponema pallidum that is endemic in low-income countries and and occurs at lower rates in middle-income and high-income countries. The disease is of both individual and public health importance and, in addition to its direct morbidity, increases risk of HIV infection and can cause lifelong morbidity in children born to infected mothers. Without treatment the disease can progress over years through a series of clinical stages and lead to… 
Diagnosis and Management of Syphilis in Patients With HIV Co-infection
TLDR
Syphilis infections in PLHIV are common and increasing and a low index of suspicion and testing with appropriate, rapid treatment should decrease the significant morbidity associated with this infection.
Syphilis: A great imitator.
TLDR
The aim is to highlight contemporary ideas and findings on syphilis so that not only is an accurate diagnosis of syphilis made and recognized treatment given, but also necessary measures, such as counseling to exclude other STIs and to prevent reinfection, partner notification, and public health epidemiology as for any other infectious disease, are not forgotten.
Early syphilis: risk factors and clinical manifestations focusing on HIV-positive patients
TLDR
HIV-positive patients were found to engage more often in sexual behaviors associated with syphilis than HIV-negative patients and molecular typing did not conclusively explain clinical presentation in relation to specific T.pallidum strains.
Sexually Acquired Syphilis. Part 2: Laboratory diagnosis, management, and prevention.
TLDR
Testing for and management of sexually acquired syphilis and screening of populations at higher risk for syphilis is recommended by the Centers for Disease Control and Prevention, the U.S. Preventive Services Task Force, and the World Health Organization.
Syphilis in Adolescents and Young Adults
TLDR
This chapter examines the changing epidemiology of syphilis as well as the microbiology and pathophysiology and clinical manifestations at different stages of the syphilitic infection.
Predictors of serological cure after penicillin therapy in HIV-negative patients with early syphilis in Shenzhen, China
TLDR
The study indicated that the syphilis stage and baseline serum titer were crucial factors associated with serological cure, and a higher percentage of early syphilis patients achievedSerological cure two years after treatment.
Imaging of Diffuse Neurosyphilis Affecting the Corticospinal Tracts and Cerebellum
TLDR
A 36-yearold female with a history of alcohol use disorder, transferred to the acute rehabilitation unit (ARU) after presenting with 2 months of ataxia, bilateral lower extremity weakness, and paresthesia, is diagnosed with neurosyphilis, supported by cerebrospinal fluid studies and reversal of MRI findings with treatment.
Syphilis-Related Musculoskeletal Manifestations
Syphilis is a chronic sexually transmitted infection due to the spirochetal bacterium Treponema pallidum (TP) subspecies Pallidum, the overall incidence of which is recently increasing among the
Sexually Acquired Syphilis. Part 1: Historical aspects, microbiology, epidemiology, and clinical manifestations.
TLDR
Historical aspects, microbiology, epidemiology, and clinical manifestations of sexually acquired syphilis are reviewed, which include protean and often include mucocutaneous manifestations.
Weaknesses in primary health care favor the growth of acquired syphilis
TLDR
The weakness of primary health care linked to population size may have favored the growth of the acquired syphilis epidemic in Brazilian cities.
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References

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TLDR
The prozone phenomenon is a false-negative reaction to a serologic test that occurs when very high antibody titers in the serum prevent the formation of the antibody-antigen lattice needed to visualize a flocculation reaction.
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TLDR
The genetic basis of T. pallidum macrolide resistance and the potential of this spirochete to develop additional antibiotic resistance that could seriously compromise syphilis treatment and control are discussed.
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Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries, and the incidence varies significantly with geographic location.
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TLDR
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TLDR
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TLDR
Several important questions regarding the management of syphilis remain unanswered and should be a priority for future research.
Clinical Manifestations of Early Syphilis by HIV Status and Gender: Results of the Syphilis and HIV Study
TLDR
Overall, HIV infection had a small effect on the clinical manifestations of primary and secondary syphilis in HIV-infected and HIV-uninfected patients.
Biological Basis for Syphilis
SUMMARY Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp. pallidum. Clinical manifestations separate the disease into stages; late stages of disease are now
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