Syntrophins and dystrobrevins: defining the dystrophin scaffold at synapses.

  title={Syntrophins and dystrobrevins: defining the dystrophin scaffold at synapses.},
  author={Douglas E. Albrecht and Stanley C. Froehner},
  volume={11 3},
Dystrophin and its associated proteins were originally identified in skeletal muscle, where the complex provides mechanical stabilization to the sarcolemma during contraction. However, the dystrophin complex is also present at membrane specializations in many non-muscle cells, including synaptic sites in neurons. The function of the dystrophin complex at these sites is still unknown, but emerging results suggest that the dystrophin complex can function as a scaffold for signaling proteins. In… CONTINUE READING
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