Syntons, metabolons and interactons: an exact graph-theoretical approach for exploring neighbourhood between genomic and functional data

@article{Boyer2005SyntonsMA,
  title={Syntons, metabolons and interactons: an exact graph-theoretical approach for exploring neighbourhood between genomic and functional data},
  author={Fr{\'e}d{\'e}ric Boyer and Anne Morgat and Laurent Labarre and Jo{\"e}l Pothier and Alain Viari},
  journal={Bioinformatics},
  year={2005},
  volume={21 23},
  pages={
          4209-15
        }
}
MOTIVATION Modern comparative genomics does not restrict to sequence but involves the comparison of metabolic pathways or protein-protein interactions as well. Central in this approach is the concept of neighbourhood between entities (genes, proteins, chemical compounds). Therefore there is a growing need for new methods aiming at merging the connectivity information from different biological sources in order to infer functional coupling. RESULTS We present a generic approach to merge the… CONTINUE READING

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