Synthetically prepared Amadori‐glycated phosphatidylethanolamine can trigger lipid peroxidation via free radical reactions

@article{Oak2000SyntheticallyPA,
  title={Synthetically prepared Amadori‐glycated phosphatidylethanolamine can trigger lipid peroxidation via free radical reactions},
  author={Jeong‐Ho Oak and Kiyotaka Nakagawa and Teruo Miyazawa},
  journal={FEBS Letters},
  year={2000},
  volume={481}
}
A Convenient Method for Preparation of High‐Purity, Amadori‐Glycated Phosphatidylethanolamine and Its Prooxidant Effect
TLDR
The results indicate that Amadori‐PE is a considerable risk factor that may cause membrane lipid peroxidation in the pathogenesis of diabetes and aging.
UV analysis of Amadori-glycated phosphatidylethanolamine in foods and biological samples.
TLDR
This study synthesized the Amadori products derived from the glycation of phosphatidylethanolamine (PE) using solid phase extraction followed by HPLC, and testing biological materials showedAmadori-PE (Glc-PE) was detectable in rat plasma.
Amadori-Glycated Phosphatidylethanolamine, a Potential Marker for Hyperglycemia, in Streptozotocin-Induced Diabetic Rats
TLDR
The results suggest that Amadori-PE may be a useful predictive marker for hyperglycemia, particularly in the early stages of diabetes.
Analysis of Amadori‐glycated Phosphatidylethanolamine in the Plasma of Healthy Subjects and Diabetic Patients by Liquid Chromatography–Tandem Mass Spectrometry
TLDR
It is likely that pyridoxal 5′‐phosphate acts as a lipid glycation inhibitor in vivo, and this may contribute to diabetes prevention.
Identification and quantification of phosphatidylethanolamine-derived glucosylamines and aminoketoses from human erythrocytes--influence of glycation products on lipid peroxidation.
TLDR
It could be shown that Amadori-PE extensively promotes lipid peroxidation even in the absence of transition metal ions like Cu(2+) and Fe(3+), which is supposed to be at least partially caused by the glycation of aminophospholipids.
Identification of free radicals in oxidized and glycoxidized phosphatidylethanolamines by spin trapping combined with tandem mass spectrometry.
TLDR
Results suggested the presence of more sites susceptible to oxidation in glycated PLPE, which may be responsible for the increase in the oxidative reaction rate occurring in Glycated PEs.
Tandem Mass Spectrometry Analysis of Amadori‐Glycated Phosphatidylethanolamine in Human Plasma
TLDR
Results indicate that plasma Amadori‐PE‐glycated lipid product formed under hyperglycemic conditions is an inducer of membrane lipid peroxidation, and therefore lipid glycation plays an active part in the development of human disease.
Photooxidation of glycated and non-glycated phosphatidylethanolamines monitored by mass spectrometry.
TLDR
A model, based on mass spectrometry (MS) analysis, is developed to identify photooxidative degradation of selected PE and glycated PEs and advanced glycated photooxidation products may have a deleterious role in the etiology of diabetic retinopathy and in diabetic retinal microvascular complications.
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TLDR
CME inhibited detection of advanced glycation end product (AGE)-modified protein in a competitive enzyme-linked immunosorbent assay using an anti-AGE antibody previously shown to recognize CML, suggesting that carboxymethyl-PE may be a component of AGE lipids detected in AGE low density lipoprotein.
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The amino-carbonyl reaction (Maillard reaction), also known as glycation, of egg-yolk phosphatidylethanolamine (PE) was induced by incubating PE (50 mg/ml) with D-glucose (222 mM) in a methanol
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Inclusion of glucosylated phosphatidylethanolamine in the surface lipid monolayer of the LDL resulted in rapid loss of polyunsaturated cholesteryl esters from the interior of the particle during oxidation.
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TLDR
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TLDR
Results indicate that glucosylation of PtdEtn in LDL accounts for the entire effect of LDL glycation on macrophage uptake and CE and TG accumulation and, therefore, the increased atherogenic potential of LDL in hyperglycemia.
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