Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives

@article{Shults2012SyntheticTO,
  title={Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives},
  author={E. E. Shulˈts and S. S. Patrushev and A. V. Belovodskii and Makhmut M. Shakirov and Tatyana V. Rybalova and A. G. Pokrovskii and Maria Pokrovskii and Genrikh A Tolstikov and Sergazy M Adekenov},
  journal={Chemistry of Natural Compounds},
  year={2012},
  volume={48},
  pages={245-249}
}
13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)-eudesma-4(5),11(13)-dien-6α,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937 tumor models showed promise for the modification.