Synthetic thermoreversible polymers are compatible with osteoinductive activity of recombinant human bone morphogenetic protein 2.

@article{Gao2002SyntheticTP,
  title={Synthetic thermoreversible polymers are compatible with osteoinductive activity of recombinant human bone morphogenetic protein 2.},
  author={T. J Gao and Niki A Kousinioris and John M. Wozney and Shelley R. Winn and Hasan Uludağ},
  journal={Tissue engineering},
  year={2002},
  volume={8 3},
  pages={429-40}
}
Recombinant human bone morphogenetic protein 2 (rhBMP-2) is currently in clinical studies as part of an implantable device that contains a biomaterial carrier. Implant retention of rhBMP-2 by the biomaterial carrier is important for the osteoinductive activity. To control in situ retention of rhBMP-2, thermoreversible polymers were synthesized and characterized, and their compatibility with rhBMP-2-induced osteoinduction was investigated. The results indicated that polymers with a controlled… CONTINUE READING