Synthetic sustained gene delivery systems.

  title={Synthetic sustained gene delivery systems.},
  author={Ankit Agarwal and S K Surya K Mallapragada},
  journal={Current topics in medicinal chemistry},
  volume={8 4},
Gene therapy today is hampered by the need of a safe and efficient gene delivery system that can provide a sustained therapeutic effect without cytotoxicity or unwanted immune responses. Bolus gene delivery in solution results in the loss of delivered factors via lymphatic system and may cause undesired effects by the escape of bioactive molecules to distant sites. Controlled gene delivery systems, acting as localized depot of genes, provide an extended sustained release of genes, giving… CONTINUE READING