Synthetic studies on N-alkoxyamines: a mild and broadly applicable route starting from nitroxide radicals and aldehydes.


A broad variety of 2,2,6,6-tetramethylpiperidine-based N-alkoxyamines were prepared in a newly found reaction. By means of a copper-catalyzed fragmentation reaction of aldehyde peroxides in the presence of TEMPO or TEMPO derivatives, N-alkoxyamines were obtained in moderate to good yields. 
DOI: 10.1021/jo802403j


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