Synthetic spectroscopic models related to coenzymes and base pairs. VII. Stacking interactions in tRNA; the

H. Iwamura; N. Leonard; J. Eisinger

DOI:10.1073/PNAS.65.4.1025

Corpus ID: 21161440

Synthetic spectroscopic models related to coenzymes and base pairs. VII. Stacking interactions in tRNA; the "bend" at dimethylguanosine.

@article{Iwamura1970SyntheticSM,
  title={Synthetic spectroscopic models related to coenzymes and base pairs. VII. Stacking interactions in tRNA; the "bend" at dimethylguanosine.},
  author={H. Iwamura and N. Leonard and J. Eisinger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1970},
  volume={65 4},
  pages={
          1025-32
        }
}

H. Iwamura, N. Leonard, J. Eisinger

Published 1970

Chemistry, Medicine

Proceedings of the National Academy of Sciences of the United States of America

We have examined the stacking interactions of N(2)-dimethyl-guanosine with the nucleosides, e.g., adenosine and cytidine, found adjacent to it in certain tRNA's, by the use of model compounds in which the trimethylene bridge was substituted for the ribose-phosphate-ribose linkage. From the hypochromism exhibited by synthetic 9-[3-(aden-9-yl)propyl]-2-dimethylaminopurine-6-one (IV) and by 9-[3-(cytos-1-yl)propyl]2-dimethylaminopurin-6-one in aqueous solution (VI) it is appearent that the… CONTINUE READING

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