Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development

  title={Synthetic self-patterning and morphogenesis in mammalian cells: a proof-of-concept step towards synthetic tissue development},
  author={{\'E}lise Cachat and Weijia Liu and Jamie A. Davies},
This study reports a proof-of-concept study as a step toward synthetic-biological morphogenesis of tissues. Events in normal animal development usually follow the sequence: patterning → differential gene expression → morphogenesis. A synthetic biological approach to development might follow a similar sequence, with each stage under the control of synthetic biological modules. The authors have constructed and published a synthetic module that drives self-organised patterning of mammalian cell… 

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