Synthetic segments of the mammalian beta AR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C.

@article{Blake1987SyntheticSO,
  title={Synthetic segments of the mammalian beta AR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C.},
  author={Allan D. Blake and Richard A. Mumford and H. Vincent Strout and Eve E. Slater and Catherine D. Strader},
  journal={Biochemical and biophysical research communications},
  year={1987},
  volume={147 1},
  pages={168-73}
}
Desensitization of the beta-adrenergic receptor has been correlated in some cell systems with receptor phosphorylation. Various kinases have been implicated in these phosphorylation processes, including both cAMP-dependent protein kinase and protein kinase C. In the present study, we have utilized the protein sequence information obtained from the cloning of the mammalian beta-adrenergic receptor to prepare synthetic peptides corresponding to regions of the receptor which would be predicted to… CONTINUE READING