Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors.

@article{Li2011SyntheticRA,
  title={Synthetic routes and biological evaluation of largazole and its analogues as potent histone deacetylase inhibitors.},
  author={Shang Li and Hequan Yao and Jinyi Xu and Sheng Jiang},
  journal={Molecules},
  year={2011},
  volume={16 6},
  pages={4681-94}
}
Natural products with interesting biological properties and structural diversity have often served as valuable lead drug candidates for the treatment of various human diseases. Largazole, isolated from the marine cyanobacterium Symploca sp. has exhibited potent inhibitory activity against many cancer cell lines. Besides, it shows remarkable selectivity between transformed and nontransformed cells, which is the main disadvantage of other antitumor natural products such as paclitaxel and… CONTINUE READING

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Total Synthesis of Largazole - Devolution of a Novel Synthetic Strategy

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Highly Influential
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