Synthetic route to chiral tetrahydroquinoxalines via ring-opening of activated aziridines.

Abstract

A highly regio- and stereoselective route for the synthesis of racemic and nonracemic tetrahydroquinoxalines via the S(N)2-type ring-opening of activated aziridines with 2-bromoanilines followed by the Pd-catalyzed intramolecular C-N bond formation is described.

DOI: 10.1021/ol2023906

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Cite this paper

@article{Ghorai2011SyntheticRT, title={Synthetic route to chiral tetrahydroquinoxalines via ring-opening of activated aziridines.}, author={Manas K Ghorai and Ashis Kumar Sahoo and Sarvesh Kumar}, journal={Organic letters}, year={2011}, volume={13 22}, pages={5972-5} }