Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses

@inproceedings{Ketzer2012SyntheticRF,
  title={Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses},
  author={Patrick Ketzer and Simon F. Haas and Sarah Engelhardt and J{\"o}rg S Hartig and Dirk M Nettelbeck},
  booktitle={Nucleic acids research},
  year={2012}
}
Therapeutic gene transfer by replication-defective viral vectors or, for cancer treatment, by replication-competent oncolytic viruses shows high promise for treatment of major diseases. To ensure safety, timing or dosing in patients, external control of therapeutic gene expression is desirable or even required. In this study, we explored the potential of artificial aptazymes, ligand-dependent self-cleaving ribozymes, as an innovative tool for regulation of therapeutic gene expression… CONTINUE READING
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