Synthetic reversal of epigenetic silencing.

@article{Haynes2011SyntheticRO,
  title={Synthetic reversal of epigenetic silencing.},
  author={Karmella A. Haynes and Pamela A. Silver},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 31},
  pages={27176-82}
}
Controlling cell fate-determining gene expression is key to stem cell differentiation, tissue regeneration, and cancer therapy. To date, custom-built transcription factors recognize the information encoded in specific DNA sequences. Chromatin proteins undergo covalent modifications and form complexes that encode a second layer of information that determines proximal gene activity. Here, we employ a novel gene-targeting approach that exploits a specific chromatin modification to reactivate… CONTINUE READING
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Senescence-associated phenotypes in Pc-TF-expressing U2OS cells. A, histograms of senescence-associated -gal activity detected by C12FDG staining and flow cytometry

  • E. Bernstein, E. M. Duncan, O. Masui, J. Gil, E. Heard, C. D. Allis
  • Synthetic Reversal of Epigenetic Silencing AUGUST
  • 2011
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