Synthetic quorum-sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device

Abstract

To utilize biofilms for chemical transformations in biorefineries they need to be controlled and replaced. Previously, we engineered the global regulator Hha and cyclic diguanylate-binding BdcA to create proteins that enable biofilm dispersal. Here we report a biofilm circuit that utilizes these two dispersal proteins along with a population-driven quorum… (More)
DOI: 10.1038/ncomms1616

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