Synthetic polyamines promote rapid lamellipodial growth by regulating actin dynamics.

Abstract

Cellular protrusions involved in motile processes are driven by site-directed assembly of actin filaments in response to Rho-GTPase signalling. So far, only chemical compounds depolymerizing actin or stabilizing filaments, inhibiting N-WASP, Arp2/3 or formins, have been used to eliminate the formation of protrusions, while Rho-GTPase-dominant positive… (More)
DOI: 10.1038/ncomms3165

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