Synthetic peptides of human lysosomal cathepsin G with potent antipseudomonal activity.

@article{Shafer1993SyntheticPO,
  title={Synthetic peptides of human lysosomal cathepsin G with potent antipseudomonal activity.},
  author={William M. Shafer and Michele E Shepherd and B Boltin and Lance Wells and J. Pohl},
  journal={Infection and immunity},
  year={1993},
  volume={61 5},
  pages={1900-8}
}
Enzymatically active and inactive (diisopropylfluorophosphate-treated) cathepsin G exerted antibacterial action in vitro against Staphylococcus aureus, whereas only enzymatically active cathepsin G displayed bactericidal action against Pseudomonas aeruginosa. In order to further test the requirement for protease activity for the antipseudomonal action of cathepsin G, synthetic peptides spanning the full-length mature protein were prepared and examined for antibacterial action. Surprisingly… CONTINUE READING
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