Synthetic peptides as model substrates for the study of the specificity of the polycation-stimulated protein phosphatases.

@article{Agostinis1990SyntheticPA,
  title={Synthetic peptides as model substrates for the study of the specificity of the polycation-stimulated protein phosphatases.},
  author={Patrizia Agostinis and Jozef Goris and Lorenzo A Pinna and F Marchiori and John W. Perich and Helmut E. Meyer and Wilfried Merlevede},
  journal={European journal of biochemistry},
  year={1990},
  volume={189 2},
  pages={235-41}
}
The substrate specificity of the different forms of the polycation-stimulated (PCS, type 2A) protein phosphatases and of the active catalytic subunit of the ATP, Mg-dependent (type 1) phosphatase (AMDC) was investigated, using synthetic peptides phosphorylated by either cyclic-AMP-dependent protein kinase or by casein kinase-2. The PCS phosphatases are very efficient toward the Thr(P) peptides RRAT(P)VA and RRREEET(P)EEE when compared with the Ser(P) analogues RRAS(P)VA and RRREEES(P)EEEAA… CONTINUE READING
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