Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells

@article{Melkoumian2010SyntheticPS,
  title={Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells},
  author={Zara K. Melkoumian and Jennifer L. Weber and David M. Weber and Andrei Gennadyevich Fadeev and Yue Fei Zhou and Paula J. Dolley-Sonneville and Jinhua Yang and Liqun Qiu and Catherine A Priest and Christopher Bankole Shogbon and Arthur Winston Martin and Jodelle Karen Nelson and Peter Christopher West and James P. Beltzer and Santona Pal and Ralph Brandenberger},
  journal={Nature Biotechnology},
  year={2010},
  volume={28},
  pages={606-610}
}
Human embryonic stem cells (hESCs) have two properties of interest for the development of cell therapies: self-renewal and the potential to differentiate into all major lineages of somatic cells in the human body. Widespread clinical application of hESC-derived cells will require culture methods that are low-cost, robust, scalable and use chemically defined raw materials. Here we describe synthetic peptide-acrylate surfaces (PAS) that support self-renewal of hESCs in chemically defined, xeno… CONTINUE READING
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Defined culture conditions of human embryonic stem cells.

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