Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.

@article{Hamada2007SyntheticOP,
  title={Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials.},
  author={Y. Hamada and H. Egusa and Y. Kaneda and I. Hirata and N. Kawaguchi and Takafumi Hirao and Takuya Matsumoto and M. Yao and Kiyoshi Daito and Mayuka Suzuki and H. Yatani and M. Daito and M. Okazaki and N. Matsuura},
  journal={Dental materials journal},
  year={2007},
  volume={26 4},
  pages={
          487-92
        }
}
We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity in vitro and in vivo. In the present study, the focus points were on the in vitro effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its in vivo effect on bone tissue formation when grafts made of CO3Ap-collagen sponge- as a scaffold biomaterial containing the SVVYGLR motif - were implanted. SVVYGLR peptide promoted bone marrow stromal cell proliferation. When a… Expand
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