Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies.

@article{Favero2010SyntheticNR,
  title={Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies.},
  author={Giovani Mastrant{\^o}nio Favero and Raul C Maranh{\~a}o and Durvanei Augusto Maria and D{\'e}bora Levy and S{\'e}rgio Paulo Bydlowski},
  journal={Biological research},
  year={2010},
  volume={43 4},
  pages={
          439-44
        }
}
7-ketocholesterol (7-KC) differs from cholesterol by a functional ketone group at C7. It is an oxygenated cholesterol derivative (oxysterol), commonly present in oxidized low-density lipoprotein (LDL). Oxysterols are generated and participate in several physiologic and pathophysiologic processes. For instance, the cytotoxic effects of oxidized LDL have been widely attributed to bioactive compounds like oxysterols. The toxicity is in part due to 7-KC. Here we aimed to demonstrate the possibility… CONTINUE READING

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