Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4.

@article{Hazeldine2005SyntheticMO,
  title={Synthetic modification of the 2-oxypropionic acid moiety in 2-\{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy\}propionic acid (XK469), and consequent antitumor effects. Part 4.},
  author={Stuart T. Hazeldine and Lisa Marie Polin and Juiwanna Kushner and K Ian White and Thomas H. Corbett and Jerome P. Horwitz},
  journal={Bioorganic & medicinal chemistry},
  year={2005},
  volume={13 12},
  pages={3910-20}
}
The criteria for the activity of 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid (SH80) against transplanted tumors in mice established in previous studies, require a (7-halo-2-quinoxalinoxy)- or a (7-halo-2-quinolinoxyl)-residue, respectively, bridged via a 1,4-OC(6)H(4)O-linker to C(2) of propionic acid. The present work demonstrates that substitution of fluorine at the 3-position of the 1,4-OC(6)H(4)O-linker of… CONTINUE READING