Synthetic microRNA cassette dosing: pharmacokinetics, tissue distribution and bioactivity.

@article{Wang2012SyntheticMC,
  title={Synthetic microRNA cassette dosing: pharmacokinetics, tissue distribution and bioactivity.},
  author={Hongyan Wang and Ming Chih Chiu and Zhiliang Xie and Michael Chiu and Zhongfa Liu and Ping Ping Chen and Shujun Liu and John C. Byrd and Natarajan Muthusamy and Ramiro Garzon and Carlo M. Croce and Guido Marcucci and Kenneth K Y Chan},
  journal={Molecular pharmaceutics},
  year={2012},
  volume={9 6},
  pages={1638-44}
}
MicroRNAs (miRs) are deregulated in cancer and leukemia. Restoring aberrantly downregulated tumor suppressor miRs or antagonizing overexpressed oncogenic miRs in malignant cells by synthetic RNA oligonucleotides represents a potentially novel therapeutic approach in cancer and leukemia. However, given the complex networking and concurrent deregulation of… CONTINUE READING