Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.

@article{Winding2002SyntheticMM,
  title={Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.},
  author={Bent Winding and R Nicamhlaoibh and Henriette Misander and Pernille H\oegh-Andersen and Thomas Levin Andersen and Claus Holst-Hansen and A Heegaard and Niels Taekker Foged and Nils Bruenner and Jean-Marie Delaiss{\'e}},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 6},
  pages={1932-9}
}
PURPOSE Breast cancer frequently leads to incurable bone metastasis. Essential requirements for the development of bone metastasis are cell-cell and cell-matrix interactions, release of bioactive growth factors and cytokines, and removal of large amounts of bone matrix. Matrix metalloproteinases (MMPs) play an important role in all of these processes, but the possibility of using synthetic MMP inhibitors to decrease bone metastasis has received little attention. EXPERIMENTAL DESIGN In the… CONTINUE READING

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Effects of parathyroid hormone (PTH) and 1938 MMP Inhibition Reduces Cancer-induced

  • Y. Kawashima-Ohya, H. Satakeda, +8 authors Y. Kato
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