Synthetic mammalian riboswitches based on guanine aptazyme.

@article{Nomura2012SyntheticMR,
  title={Synthetic mammalian riboswitches based on guanine aptazyme.},
  author={Yoko Nomura and Deepak Kumar and Yohei Yokobayashi},
  journal={Chemical communications},
  year={2012},
  volume={48 57},
  pages={7215-7}
}
Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.