Synthetic lethality--a new direction in cancer-drug development.

@article{Iglehart2009SyntheticLN,
  title={Synthetic lethality--a new direction in cancer-drug development.},
  author={James Dirk Iglehart and Daniel P. Silver},
  journal={The New England journal of medicine},
  year={2009},
  volume={361 2},
  pages={189-91}
}
In this issue of the Journal, Fong et al. report the results of a phase 1 trial of a new cancer therapy involving 60 patients (ClinicalTrials.gov number, NCT00516373).1 Readers may be surprised by the editors’ decision to publish a small early-stage trial, but this trial not only reports important results — it also points to a new direction in the development of anticancer drugs. Modern cancerdrug discovery focuses on finding new therapies with few side effects by leveraging advances in the… CONTINUE READING
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