Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum.

Abstract

Discovering the mechanisms by which cell signaling controls the cell cycle of the human malaria parasite Plasmodium falciparum is fundamental to designing more effective antimalarials. To better understand the impacts of melatonin structure and function on the cell cycle of P. falciparum, we have synthesized two families of structurally-related melatonin… (More)
DOI: 10.1016/j.ejmech.2014.03.055

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@article{Schuck2014SyntheticIA, title={Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum.}, author={Desir{\'e}e Cigaran Schuck and Alessandro Kappel Jord{\~a}o and Myna Nakabashi and Anna Cl{\'a}udia Cunha and Vitor Francisco Ferreira and C{\'e}lia R. S. Garcia}, journal={European journal of medicinal chemistry}, year={2014}, volume={78}, pages={375-82} }