Synthetic human parathyroid hormone 1-34 replacement therapy: a randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism.

@article{Winer2012SyntheticHP,
  title={Synthetic human parathyroid hormone 1-34 replacement therapy: a randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism.},
  author={Karen K. Winer and Bo Zhang and Joseph A. Shrader and Donna J Peterson and Michaele R Smith and Paul S. Albert and Gordon B. Cutler},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 2},
  pages={391-9}
}
CONTEXT Vitamin D therapy for hypoparathyroidism does not restore PTH-dependent renal calcium reabsorption, which can lead to renal damage. An alternative approach, PTH 1-34 administered twice daily, provides acceptable long-term treatment but is associated with nonphysiological serum calcium fluctuation. OBJECTIVE Our objective was to compare continuous PTH 1-34 delivery, by insulin pump, with twice-daily delivery. RESEARCH DESIGN AND METHODS In a 6-month, open-label, randomized, crossover… CONTINUE READING
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