Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro

@article{Gonindard1997SyntheticHA,
  title={Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro},
  author={Christophe Gonindard and Cesare Bergonzi and Colette C Denier and Christian Sergheraert and Alain Kla{\'e}b{\'e} and Louis Chavant and Etienne Hollande},
  journal={Cell Biology and Toxicology},
  year={1997},
  volume={13},
  pages={141-153}
}
The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy) was shown to be cytotoxic (between 10-3 mol/L and 10-7 mol/L) toward normal human MRC-5 fibroblasts, human cancerous keratinocytes (SCL-1 cell line), and human cancerous pancreatic duct cells… CONTINUE READING

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Constituents of the higher fungi. Part II. The synthesis of hispidin

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  • J Chem Soc
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Highly Influential
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