Synthetic gene networks in mammalian cells.

@article{Weber2010SyntheticGN,
  title={Synthetic gene networks in mammalian cells.},
  author={Wilfried Weber and Martin Fussenegger},
  journal={Current opinion in biotechnology},
  year={2010},
  volume={21 5},
  pages={690-6}
}
The design and construction of synthetic gene circuits with complex spatiotemporal dynamics was pioneered in bacteria, but it took almost a decade until synthetic biologists were able to construct genetic circuits with complex spatiotemporal dynamics in mammalian cells. This review highlights the most recent advances in mammalian synthetic biology, and it describes metabolite, hormone, and light-triggered genetic switches as well as the design and construction of synthetic networks that feature… CONTINUE READING

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