Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.

@article{Yu2014SyntheticDH,
  title={Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis.},
  author={Hai Yu and Kam Tong Lau and Vireak Thon and Chloe Autran and Evelyn Jantscher-Krenn and Mengyang Xue and Yanhong Li and Go Sugiarto and Jingyao Qu and Shengmao Mu and Li Ding and Lars Bode and Xi Chen},
  journal={Angewandte Chemie},
  year={2014},
  volume={53 26},
  pages={6687-91}
}
Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and α2-6-linked disialyllacto-N-tetraose (DS'LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize… CONTINUE READING