Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.

@article{Jankun2006SyntheticCM,
  title={Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.},
  author={Jerzy Jankun and Ansari Mukhtar Aleem and Sylvia Malgorzewicz and Maria Szkudlarek and Maria I. Zavodszky and David L Dewitt and Michael Feig and Steven H. Selman and Ewa Skrzypczak-Jankun},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 5},
  pages={1371-82}
}
Platelet 12-lipoxygenase (P-12-LOX) is overexpressed in different types of cancers, including prostate cancer, and the level of expression is correlated with the grade of this cancer. Arachidonic acid is metabolized by 12-LOX to 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE], and this biologically active metabolite is involved in prostate cancer progression by modulating cell proliferation in multiple cancer-related pathways inducing angiogenesis and metastasis. Thus, inhibition of P-12-LOX… CONTINUE READING

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