Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells

@inproceedings{Ali2017SyntheticCD,
  title={Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells},
  author={Norlaily Mohd Ali and Swee Keong Yeap and N Abu and Kian Lam Lim and Huynh Ky and Ahmad Zaim Mat Pauzi and Wan Yong Ho and Sheau Wei Tan and han Kiat alan-Ong and Seema Zareen and Noorjahan Banu Mohamed Alitheen and Muhammad Nadeem Akhtar},
  booktitle={Cancer Cell International},
  year={2017}
}
Curcumin is a lead compound of the rhizomes of Curcuma longa and possess a broad range of pharmacological activities. Chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism. Despite of its strong biological properties, curcumin has yet been recommended as a therapeutic agent because of its poor bioavailability. A curcumin derivative (Z)-3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (DK1) was synthesized and its cytotoxicity was tested on breast… CONTINUE READING
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