Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology

@article{Schmidt2012SyntheticCI,
  title={Synthetic constructs in/for the environment: Managing the interplay between natural and engineered Biology},
  author={M. Schmidt and V. de Lorenzo},
  journal={Febs Letters},
  year={2012},
  volume={586},
  pages={2199 - 2206}
}
  • M. Schmidt, V. de Lorenzo
  • Published 2012
  • Biology, Medicine
  • Febs Letters
  • The plausible release of deeply engineered or even entirely synthetic/artificial microorganisms raises the issue of their intentional (e.g. bioremediation) or accidental interaction with the Environment. Containment systems designed in the 1980s–1990s for limiting the spread of genetically engineered bacteria and their recombinant traits are still applicable to contemporary Synthetic Biology constructs. Yet, the ease of DNA synthesis and the uncertainty on how non‐natural properties and strains… CONTINUE READING
    83 Citations

    Topics from this paper

    Synthetic bugs on the loose: containment options for deeply engineered (micro)organisms.
    • 43
    • PDF
    Building-in biosafety for synthetic biology.
    • 93
    Synthetic Genomics and Synthetic Biology Applications Between Hopes and Concerns
    • 46
    • PDF
    Preparing synthetic biology for the world
    • 88
    • PDF
    Biocontainment of genetically modified organisms by synthetic protein design
    • 241
    • PDF
    Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications
    • 7
    • PDF
    The Synthetic Nature of Biology
    • 17

    References

    SHOWING 1-10 OF 112 REFERENCES
    Genetically modified organisms for the environment: stories of success and failure and what we have learned from them.
    • I. Cases, V. de Lorenzo
    • Biology, Medicine
    • International microbiology : the official journal of the Spanish Society for Microbiology
    • 2005
    • 193
    • PDF
    Environmental biosafety in the age of Synthetic Biology: Do we really need a radical new approach?
    • V. de Lorenzo
    • Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2010
    • 12
    The farther, the safer: a manifesto for securely navigating synthetic species away from the old living world
    • P. Marliere
    • Computer Science, Medicine
    • Systems and Synthetic Biology
    • 2009
    • 83
    • PDF
    Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids
    • 119
    Xenobiology: A new form of life as the ultimate biosafety tool
    • M. Schmidt
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2010
    • 145
    • PDF
    Recombinant bacteria for environmental release: what went wrong and what we have learnt from it.
    • V. de Lorenzo
    • Medicine
    • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
    • 2009
    • 29
    • PDF
    Chemical Synthetic Biology
    • 13
    The second wave of synthetic biology: from modules to systems
    • 1,051
    • PDF
    pBAM1: an all-synthetic genetic tool for analysis and construction of complex bacterial phenotypes
    • 117
    • PDF
    The Behavior of Bacteria Designed for Biodegradation
    • 109