Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry

  title={Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry},
  author={Agnieszka Wołoś and Rafał Roszak and Anna Żądło-Dobrowolska and Wiktor Beker and Barbara Mikulak-Klucznik and Grzegorz Sp{\'o}lnik and Mirosław Dygas and Sara Szymku{\'c} and Bartosz A. Grzybowski},
Mapping primordial reaction networks Chemists seeking to understand the origins of life have published a wide range of reactions that may have yielded the building blocks of proteins, nucleic acids, and lipids from simple precursors. Wołos et al. scoured the literature to document each such reaction class and then wrote software that applied the reactions first to the simplest compounds such as cyanide, water, and ammonia, and then iteratively to each successive generation of products. The… 

Prebiotic Reaction Networks in Water

The future of prebiotic chemistry lies in better understanding the genuine complexity that can result from reaction networks and the construction of a centralised database of reactions useful for predicting potential network evolution is emphasised.

Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network

It has been shown that systems of chemical reactions exhibit well-defined self-organization in varying environments, providing a potential mechanism for chemical evolution processes that bridge the gap between prebiotic building blocks and life’s origin.

Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction

It is demonstrated how complex systems of chemical reactions exhibit well-defined self-organization in response to varying environmental conditions, which allows the compositional complexity of the reaction products to be controlled as a function of factors such as feedstock and catalyst availability.

Automated Exploration of Prebiotic Chemical Reaction Space: Progress and Perspectives

Prebiotic chemistry often involves the study of complex systems of chemical reactions that form large networks with a large number of diverse species. Such complex systems may have given rise to

The hierarchical organization of autocatalytic reaction networks and its relevance to the origin of life

It is shown that, depending on the topological relationship of SDASs in a chemical reaction network, a food-driven system can accrete complexity in a historically contingent manner, governed by rare seeding events, and sequential activation of trophically organizedSDASs by seed chemicals could be a mechanism of gradual complexification from relatively simple abiotic reactions to more complex life-like systems.

Small-molecule autocatalytic networks are universal metabolic fossils

The wide distribution of small-molecule reflexively autocatalytic food-generated networks indicates that molecular reproduction may be much more prevalent in the Universe than hitherto predicted.

Title : A mechanism of abiogenesis based on complex reaction networks organized by seed-dependent autocatalytic systems Author Line

Life is the canonical example of a complex system, consisting of diverse chemical components that are organized in a specific way that allows perpetuation of the living state. In contrast, the

Peptides before and during the nucleotide world: an origins story emphasizing cooperation between proteins and nucleic acids

Light is shed on the role of early peptides and small proteins before and during the nucleotide world, in which nascent life fully grasped the potential of primordial proteins, and which has left an imprint on the idiosyncratic properties of extant proteins.

The Prebiotic Kitchen: A Guide to Composing Prebiotic Soup Recipes to Test Origins of Life Hypotheses

It is argued that developing a handful of standardized prebiotic recipes may facilitate coordination among researchers and enable the identification of the most promising mechanisms by which complex prebiotics mixtures were “tamed” during the origin of life to give rise to key living processes such as self-propagation, information processing, and adaptive evolution.

Self-Reproduction and Darwinian Evolution in Autocatalytic Chemical Reaction Systems

This review starts by evaluating theoretical studies of ACSs specifically with a view to establish the conditions required for such chemical systems to exhibit self-reproduction and Darwinian evolution, and follows with an extensive overview of experimental ACS systems.



In silico Support for Eschenmoser’s Glyoxylate Scenario

It is shown here that generative models of chemical spaces based on graph grammars make it possible to study such phenomena in a systematic manner, and previously unexplored potentially autocatalytic pathways from HCN to glyoxylate are discovered.

Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.

It is shown that precursors of ribonucleotides, amino acids and lipids can all be derived by the reductive homologation of hydrogen cyanide and some of its derivatives, and thus that all the cellular subsystems could have arisen simultaneously through common chemistry.

Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures

2-aminothiazole — a hybrid of prebiotic amino acid and nucleotide precursors — sequentially accumulates and purifies glycolaldehyde and glyceraldehyde from complex mixtures in the order required for ribonucleotide synthesis, and provides the first strategy to select natural amino acids from abiotic aldehydes and ketones.

Synthesis and breakdown of universal metabolic precursors promoted by iron

A purely chemical reaction network promoted by ferrous iron is described, in which aqueous pyruvate and glyoxylate build up 9 of the 11 intermediates of the biological Krebs (or tricarboxylic acid) cycle, including all 5 universal metabolic precursors.

Prebiotic Peptides: Molecular Hubs in the Origin of Life.

It is proposed that ample future breakthroughs in origin-of-life chemistry will stem from investigations of interconnected chemical systems in which synergistic interactions between different classes of molecules emerge.

Insights Into the Origin of Life: Did It Begin from HCN and H2O?

The results from the AINR approach show that aqueous HCN could indeed have been the source of RNA and protein precursors, but they also indicate that just the interaction of HCN with water would have sufficed to begin a series of reactions leading to the precursor.

Systems chemistry.

An impression of the state of the art of the field is given by showing a diverse number of recent highlights, including out-of-equilibrium self-assembly, chemically fuelled molecular motion, compartmentalised chemical networks and designed oscillators.

Membraneless polyester microdroplets as primordial compartments at the origins of life

This work synthesized and assembled membraneless polyester microdroplets from drying of pools of simple α-hydroxy acid monomers and showed that they can act as plausible prebiotic compartments, showing the droplets’ potential compatibility with and scaffolding ability for nascent biomolecular systems that could have coexisted in complex chemical systems.

A Chemist’s Perspective on the Role of Phosphorus at the Origins of Life

The mechanisms by which phosphate has guided prebiotic reactivity through catalysis or buffering effects, to facilitating selective transformations in neutral water provide an increasingly clear message that understanding phosphate chemistry will be a key element in elucidating the origins of life on Earth.

Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions

By using small organic molecules to build a network of organic reactions with autocatalytic, bistable and oscillatory behaviour, principles are identified that explain the ways in which dynamic networks relevant to life could have developed.