Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution

@article{Schaerli2018SyntheticCR,
  title={Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution},
  author={Yolanda Schaerli and Alba Jim{\'e}nez and Jos{\'e} M Duarte and Ljiljana Sto{\vs}i{\'c} Mihajlovi{\'c} and Julien Renggli and Mark Isalan and James Sharpe and Andreas Wagner},
  journal={Molecular Systems Biology},
  year={2018},
  volume={14}
}
Phenotypic variation is the raw material of adaptive Darwinian evolution. The phenotypic variation found in organismal development is biased towards certain phenotypes, but the molecular mechanisms behind such biases are still poorly understood. Gene regulatory networks have been proposed as one cause of constrained phenotypic variation. However, most pertinent evidence is theoretical rather than experimental. Here, we study evolutionary biases in two synthetic gene regulatory circuits… 

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