Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.

@article{Almada2019SyntheticCJ,
  title={Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.},
  author={Marta Almada and Patr{\'i}cia Alves and Bruno M. Fonseca and F{\'e}lix Carvalho and Cl{\'a}udio Rafael Queir{\'o}s and Helena Gaspar and Cristina Amaral and Nat{\'e}rcia Teixeira and Georgina Correia-da-Silva},
  journal={Toxicology letters},
  year={2019}
}
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TLDR
Overall, SCB-induced nephrotoxicity seems to be mainly regulated at the mitochondrial level, but the specific mechanisms involved require further clarification.
Toxicological profiles of selected synthetic cannabinoids showing high binding affinities to the cannabinoid receptor subtype CB1
TLDR
Genotoxic effects are in general linear over a wide concentration range and the exposure levels may be higher in epithelial cells or in serum, further experimental work is required to find out if DNA damage takes place in drug users.
Effects of cannabis tetrahydrocannabinol on endocannabinoid homeostasis in human placenta
TLDR
It is demonstrated that long-term local AEA levels are associated with a shift in the enzymatic profile to re-establish ECS homeostasis, which may disturb the delicate balance of trophoblast cells turnover leading to alterations in normal placental development and foetal growth.
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