Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.

@article{Almada2019SyntheticCJ,
  title={Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.},
  author={Marta Almada and Patr{\'i}cia Alves and Bruno M. Fonseca and F{\'e}lix Carvalho and Cl{\'a}udio Rafael Queir{\'o}s and Helena Gaspar and Cristina Amaral and Nat{\'e}rcia Teixeira and Georgina Correia-da-Silva},
  journal={Toxicology letters},
  year={2019}
}
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The aim of this review is to explore the current evidence surrounding the effects of prenatal exposure to cannabinoids and the role of the ECS in the placenta and the developing fetus.
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TLDR
The results indicated that UR-144-induced autophagic and necrotic cell death might be a consequence of elevated cytoplasmic Ca2+ levels and DAPK1 activation, however, in vivo/clinical studies are needed to identify molecular mechanisms of cardiotoxic effects of UR- 144.
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The aim of the present review is to collect the state of the art of CBs effects on hematological tumors, thus focusing on the essential topics that might be useful before moving into the clinical practice.
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