Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.

@article{Luszczki2011SyntheticCW,
  title={Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.},
  author={Jarogniew J Luszczki and Marta Misiuta-Krzesinska and Magdalena Florek and Piotr Tutka and Stanislaw J. Czuczwar},
  journal={Pharmacology, biochemistry, and behavior},
  year={2011},
  volume={98 2},
  pages={261-7}
}
The aim of this study was to determine the effect of WIN 55,212-2 mesylate (WIN--a non-selective cannabinoid CB1 and CB2 receptor agonist) on the protective action of four classical antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, and valproate) in the mouse maximal electroshock seizure (MES) model. The results indicate that WIN (10 mg/kg, i.p.) significantly enhanced the anticonvulsant action of carbamazepine, phenytoin, phenobarbital and valproate in the MES test in mice. WIN (5… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Glutamatergic Mechanisms Associated with Seizures and Epilepsy.

Cold Spring Harbor perspectives in medicine • 2015
View 6 Excerpts
Highly Influenced

The Pharmacological Basis of Cannabis Therapy for Epilepsy.

The Journal of pharmacology and experimental therapeutics • 2016
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…