Synthetic biological approaches to natural product biosynthesis.

@article{Winter2012SyntheticBA,
  title={Synthetic biological approaches to natural product biosynthesis.},
  author={Jaclyn M. Winter and Yi Tang},
  journal={Current opinion in biotechnology},
  year={2012},
  volume={23 5},
  pages={736-43}
}
Small molecules produced in Nature possess exquisite chemical diversity and continue to be an inspiration for the development of new therapeutic agents. In their host organisms, natural products are assembled and modified using dedicated biosynthetic pathways. By rationally reprogramming and manipulating these pathways, unnatural metabolites containing enhanced structural features that were otherwise inaccessible can be obtained. Additionally, new chemical entities can be synthesized by… CONTINUE READING
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