Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity.

@article{Marchalonis1994SyntheticAO,
  title={Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity.},
  author={John Jacob Marchalonis and Samuel F. Schluter and Eric Shing-Suan Wang and Keivan Dehghanpisheh and Douglas Lake and David Yocum and Allen B. Edmundson and John B. Winfield},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1994},
  volume={207 2},
  pages={129-47}
}
Immunoglobulins and their close relatives, the antigen-specific T-cell receptors, are recognition proteins that express structures which readily serve as self-immunogens. Healthy humans can produce antibodies against variable region-defined recognition structures termed idiotypes, as well as against constant region structures, and the levels of these can increase markedly in autoimmune disease; e.g., rheumatoid factors are autoantibodies directed against a conformational determinant of the… CONTINUE READING