Synthetic approaches to the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir phosphate (Tamiflu) for the treatment of influenza.

@article{Magano2009SyntheticAT,
  title={Synthetic approaches to the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir phosphate (Tamiflu) for the treatment of influenza.},
  author={Javier Magano},
  journal={Chemical reviews},
  year={2009},
  volume={109 9},
  pages={4398-438}
}
Influenza, a severe viral infection of the respiratory system, is responsible for a significant morbidity and mortality due to both annual epidemics and unpredictable pandemics. In the United States alone, 10-20% of the population is affected every year, which results in approximately 110,000 hospitalizations and more than 20,000 deaths with an estimated cost of U.S. $12 billion.1 In addition to the annual occurrence of the disease, there is a growing concern that a worldwide pandemic will… CONTINUE READING
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