Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model.

@article{Paola2016SyntheticAN,
  title={Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model.},
  author={Massimiliano de Paola and Stefania Enza Sestito and Alessandro Mariani and Christian Memo and Roberto Fanelli and Mattia Freschi and Caterina Bendotti and Valentina Calabrese and Francesco Peri},
  journal={Pharmacological research},
  year={2016},
  volume={103},
  pages={180-7}
}
Increasing evidence indicates that inflammatory responses could play a critical role in the pathogenesis of motor neuron injury in amyotrophic lateral sclerosis (ALS). Recent findings have underlined the role of Toll-like receptors (TLRs) and the involvement of both the innate and adaptive immune responses in ALS pathogenesis. In particular, abnormal TLR4 signaling in pro-inflammatory microglia cells has been related to motoneuron degeneration leading to ALS. In this study the effect of small… CONTINUE READING
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