Synthetic and Biological Studies of Juglorubin and Related Naphthoquinones.

  title={Synthetic and Biological Studies of Juglorubin and Related Naphthoquinones.},
  author={Shogo Kamo and Tatsuo Saito and Yasuha Kusakabe and Shusuke Tomoshige and Masanobu Uchiyama and Kazunori Tsubaki and Kouji Kuramochi},
  journal={The Journal of organic chemistry},
Juglorubin, juglorescein, and juglocombins A/B are naturally occurring naphthoquinone dimers isolated from Streptomyces sp. These dimers are proposed to be biogenetically derived from juglomycin C, a monomeric naphthoquinone isolated from the same Streptomyces sp. In this study, the dimerization of a juglomycin C derivative, a key step in the total syntheses of these natural products, was investigated. Juglorubin was synthesized from the minor product of the dimerization via the formation of… 
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