Synthetic analogues relevant to the structure and function of zinc enzymes.

  title={Synthetic analogues relevant to the structure and function of zinc enzymes.},
  author={Gerard Parkin},
  journal={Chemical reviews},
  volume={104 2},
  • G. Parkin
  • Published 24 January 2004
  • Chemistry, Medicine
  • Chemical reviews
Variable-temperature X-ray diffraction study of structural parameters of NH---S hydrogen bonds in triethylammonium and pyridinium silanethiolates.
All results point to the higher energy of bonding in TDST-TEA both in the solid state and in solution, indicating good stabilization of the system for a wide range of D-H...A distances.
A Hydroxyl-bridged Dinuclear Copper Complex Having Planar Structure Shows Efficient DNA Cleavage Activity in Aqueous Solution
A new dinuclear copper(II) complex, [Cu(DPA)OH]2⋅2ClO4(Cu2-DPA2, DPA = di(pyridin-2-yl)amine), was synthesized and structurally characterized. The complex crystallized in a triclinic P-1 space group,
A LADH-like Zn-MOF as an efficient bifunctional catalyst for cyanosilylation of aldehydes and photocatalytic oxidative carbon–carbon coupling reaction
Abstract The rational design of component and coordination configuration of active center is critical and useful to the development of multifunctional MOF-based catalysts. Herein, a bifunctional
A New Dimeric Copper(II) Complex of Hexyl Bis(pyrazolyl)acetate Ligand as an Efficient Catalyst for Allylic Oxidations
The present study highlights the potential of copper(II) complexes containing functionalized bis(pyrazol-1-yl)acetate ligands as efficient catalysts for allylic oxidations and shows relevant improvements with respect to classical Kharasch–Sosnovsky reactions in terms of rate and amount of reagents.
A combined experimental and theoretical rationalization of an unusual zinc(ii)-mediated conversion of 18-membered Schiff-base macrocycles to 18-membered imine–amine macrocycles with imidazolidine side rings: an investigation of their bio-relevant catalytic activities
The 2 : 2 condensation reaction of 2,6-diformyl-4-isopropyl phenol and N′-(2-aminoethyl)ethane-1,2-diamine leads to a macrocycle Schiff base ligand (H2L) with the N6O2 chromophore, which in the
A de novo binuclear zinc enzyme with DNA cleavage activity
Results indicate that the DFsc scaffold is a good model system to carry out careful structure–function relationship studies to understand key structural features that influence reactivity in natural binuclear zinc hydrolases, as it is the first report of a binuclear model system in a protein scaffold.
Aromaticity in catalysis: metal ligand cooperation via ligand dearomatization and rearomatization.
Representation of ligand systems will be highlighted and a comparison between the Milstein and the Huang pincer system will be discussed to provide theoretical and conceptual insights.
BioMetAll: Identifying Metal-Binding Sites in Proteins from Backbone Preorganization
This study shows that BioMetAll offers a versatile platform for numerous fields of research at the interface between inorganic chemistry and biology and allows to highlight the role of the preorganization of the protein backbone as a marker for metal binding.
Bioinorganic insights of the PQQ-dependent alcohol dehydrogenases.
The three types of PQQ-dependent ADHs are reviewed with special focus on their structural features and electron transfer processes, and an additional [2Fe-2S] cluster has been discovered recently.


For examples of other studies of the coordination chemistry of zinc with amino acids, small peptides, ligands that incorporate amino acid residues and carbohydrate derivatives, see
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Scorpionates: The Coordination Chemistry of Polypyrazolylborate Ligands
This work deals with polypyrazolylborates (scorpionates), a class of ligands known since 1966, which have become increasingly popular with inorganic, organometallic and co-ordination chemists since
Zinc Metalloproteases Health Dis
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The Biological Significance of Zinc for Man: Problems and Prospects and putative Therapeutic Roles for Zinc are described.
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This encyclopedic work includes authoritative coverage of atomic and molecular structure, organic chemistry (revised), inorganic, analytical, and electro- chemistry, mathematics as applied to chemistry, and more.