Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.

@article{Chhabra2003SyntheticAO,
  title={Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.},
  author={Siri Ram Chhabra and Chris Harty and Doreen S. W. Hooi and Mavis Daykin and Paul D. Williams and Gary Telford and David Idris Pritchard and Barrie W. Bycroft},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 1},
  pages={97-104}
}
Comparative immune modulatory activity for a range of synthetic analogues of a Pseudomonas aeruginosa signal molecule, N-(3-oxododecanoyl)-l-homoserine lactone (3O, C(12)-HSL), is described. Twenty-four single or combination systematic alterations of the structural components of 3O, C(12)-HSL were introduced as described. Given the already defined immunological profile of the parent compound, 3O, C(12)-HSL, these compounds were assayed for their ability to inhibit murine and human leucocyte… CONTINUE READING

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